Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 11/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.32 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2107553 | 0.87 | TRIM24 (0.36) | TRIM24CYP11B1CYP11B2ALOX5 | |
| SCHEMBL8557003 | 0.85 | TRPV1 (0.30) | TRPV1CYP11B1 | |
| SCHEMBL8552161 | 0.84 | MAP2K1 (0.32) | TRIM24 | |
| SCHEMBL2109679 | 0.81 | ALOX5 (0.37) | TRPV1ALOX5 | |
| SCHEMBL2108075 | 0.80 | TRIM24 (0.36) | TRIM24TRPV1CYP11B1CYP11B2ALOX5 | |
| SCHEMBL8556507 | 0.78 | ALOX5 (0.32) | ALOX5 | |
| SCHEMBL8979495 | 0.78 | TRIM24 (0.35) | TRIM24TRPV1CYP11B1CYP11B2 | |
| SCHEMBL8556514 | 0.78 | ATAD2 (0.39) | CYP11B1CYP11B2 | |
| SCHEMBL2108940 | 0.76 | TRIM24 (0.36) | TRIM24CYP11B1CYP11B2ALOX5 | |
| SCHEMBL2107548 | 0.76 | ALOX5 (0.43) | TRIM24TRPV1CYP11B1CYP11B2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623614-B1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1998-02-25 | — | — | EP | disclosed |
| US-5478842-A | Antiinflammatory agents, antiallergens, drugs for treatment of diseases mediated by leukotrienes | ZENECA LIMITED (GB) | 1995-12-26 | — | — | US | disclosed |
| WO-1994025453-A1 | 4-ARYL-4-HYDROXY-TETRAHYDROPYRANS AND 3-ARYL-3-HYDROXY-TETRAHYDROFURANS AS 5-LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |
| EP-0623614-A1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1994-11-09 | — | — | EP | disclosed |