Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 6/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2107553 | 0.89 | TRIM24 (0.36) | ALDH1A1GAALMNACYP1A2CYP11B1 | |
| SCHEMBL2108821 | 0.83 | ATAD2 (0.40) | ATAD2LMNACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL8553372 | 0.79 | PKM (0.42) | ALDH1A1LMNAPOLBL3MBTL1 | |
| SCHEMBL8557669 | 0.78 | TRIM24 (0.35) | CYP11B1CYP11B2 | |
| SCHEMBL8979492 | 0.78 | ATAD2 (0.39) | ATAD2ALDH1A1GAALMNACYP1A2 | |
| SCHEMBL2108075 | 0.78 | TRIM24 (0.36) | ALDH1A1GAACYP11B1CYP11B2 | |
| SCHEMBL8552161 | 0.77 | MAP2K1 (0.32) | — | |
| SCHEMBL9286206 | 0.77 | TRIM24 (0.37) | ALDH1A1GAALMNACYP1A2CYP11B1 | |
| SCHEMBL9285980 | 0.77 | TRIM24 (0.37) | ALDH1A1GAALMNACYP1A2CYP11B1 | |
| SCHEMBL9285989 | 0.77 | TRIM24 (0.37) | ALDH1A1GAALMNACYP1A2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623614-B1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1998-02-25 | — | — | EP | disclosed |
| US-5478842-A | Antiinflammatory agents, antiallergens, drugs for treatment of diseases mediated by leukotrienes | ZENECA LIMITED (GB) | 1995-12-26 | — | — | US | disclosed |
| WO-1994025453-A1 | 4-ARYL-4-HYDROXY-TETRAHYDROPYRANS AND 3-ARYL-3-HYDROXY-TETRAHYDROFURANS AS 5-LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |
| EP-0623614-A1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1994-11-09 | — | — | EP | disclosed |