Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 5/20 | 0.47 |
| ▸ | AVPR2 | P30518 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339819 | 0.83 | AVPR1A (0.60) | AVPR1AAVPR2 | |
| SCHEMBL8559548 | 0.79 | POLB (0.51) | AVPR1AAVPR2POLBHPGDALDH1A1 | |
| SCHEMBL8561629 | 0.77 | AVPR2 (0.52) | AVPR1AAVPR2KMT2ANPC1HPGD | |
| SCHEMBL8557861 | 0.77 | AVPR1A (0.45) | AVPR1AAVPR2KMT2ANPC1HPGD | |
| SCHEMBL8561685 | 0.77 | AVPR1A (0.44) | AVPR1AAVPR2KMT2ANPC1HPGD | |
| SCHEMBL8558210 | 0.77 | AVPR1A (0.44) | AVPR1AAVPR2KMT2ANPC1HPGD | |
| SCHEMBL8560422 | 0.76 | AVPR1A (0.42) | AVPR1AAVPR2KMT2ANPC1HPGD | |
| SCHEMBL8563014 | 0.76 | AVPR2 (0.51) | AVPR1AAVPR2KMT2ANPC1HPGD | |
| SCHEMBL7345725 | 0.76 | AVPR2 (0.69) | AVPR1AAVPR2ALDH1A1TSHR | |
| SCHEMBL8563827 | 0.75 | ALDH1A1 (0.47) | AVPR1AAVPR2KMT2ANPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |