Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 7/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 7/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8564026 | 0.89 | AVPR1A (0.43) | AVPR1AAVPR2NPC1RAB9AKMT2A | |
| SCHEMBL8559812 | 0.86 | MEN1 (0.46) | AVPR1AAVPR2RAB9AKMT2AALDH1A1 | |
| SCHEMBL8557861 | 0.85 | AVPR1A (0.45) | AVPR1AAVPR2NPC1RAB9AKMT2A | |
| SCHEMBL7341924 | 0.84 | AVPR1A (0.57) | AVPR1AAVPR2 | |
| SCHEMBL8562373 | 0.83 | AVPR1A (0.45) | AVPR1AAVPR2NPC1RAB9AKMT2A | |
| SCHEMBL8559548 | 0.82 | POLB (0.51) | AVPR1AAVPR2ALDH1A1HPGDLMNA | |
| SCHEMBL8558210 | 0.81 | AVPR1A (0.44) | AVPR1AAVPR2NPC1RAB9AKMT2A | |
| SCHEMBL8556372 | 0.80 | KCNJ5 (0.51) | AVPR1AAVPR2 | |
| SCHEMBL8563249 | 0.77 | AVPR2 (0.48) | AVPR1AAVPR2LMNA | |
| SCHEMBL8562797 | 0.77 | AVPR2 (0.54) | AVPR1AAVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |