Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.52 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560873 | 0.88 | ACHE (0.60) | RAB9AAVPR2AVPR1ANAMPT | |
| SCHEMBL8560660 | 0.81 | NPC1 (0.54) | NPC1RAB9AAVPR2AVPR1ANAMPT | |
| SCHEMBL8559349 | 0.81 | AVPR2 (0.60) | AVPR2AVPR1A | |
| SCHEMBL8563019 | 0.80 | AVPR2 (0.59) | AVPR2AVPR1ANAMPT | |
| SCHEMBL8560986 | 0.78 | LMNA (0.56) | AVPR2AVPR1ANAMPTMAPTLMNA | |
| SCHEMBL8558993 | 0.78 | AVPR2 (0.65) | AVPR2AVPR1A | |
| SCHEMBL8560800 | 0.78 | AVPR2 (0.79) | AVPR2AVPR1A | |
| SCHEMBL8556851 | 0.78 | AVPR2 (0.58) | MEN1KMT2AAVPR2AVPR1A | |
| SCHEMBL7369344 | 0.77 | AVPR2 (0.70) | AVPR2AVPR1A | |
| SCHEMBL8564021 | 0.76 | AVPR2 (0.61) | AVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |