Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9302744 | 0.87 | MEN1 (0.52) | KMT2AMEN1MAPK1HTR2AHTR2C | |
| SCHEMBL8558110 | 0.83 | HTR2A (0.44) | KMT2AMEN1MAPK1HTR2AHTR2C | |
| SCHEMBL27377759 | 0.82 | KMT2A (0.43) | KMT2AMEN1MAPK1PTGDR2HTR2A | |
| SCHEMBL8553972 | 0.77 | MEN1 (0.45) | KMT2AMEN1MAPK1PTGDR2HTR2A | |
| SCHEMBL8553141 | 0.77 | MEN1 (0.45) | KMT2AMEN1MAPK1PTGDR2HTR2A | |
| SCHEMBL8554000 | 0.77 | ALOX5 (0.55) | KMT2AMEN1MAPK1ALOX5POLB | |
| SCHEMBL8554628 | 0.76 | HTR2A (0.64) | KMT2AMEN1MAPK1HTR2AHTR2C | |
| SCHEMBL8558162 | 0.71 | ALOX5 (0.74) | KMT2AMEN1HTR2AHTR2CALOX5 | |
| SCHEMBL3546198 | 0.69 | HTR2C (0.42) | KMT2AMEN1MAPK1HTR2AHTR2C | |
| SCHEMBL3545521 | 0.69 | HTR2C (0.41) | KMT2AMEN1MAPK1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529452-B1 | 1,7-Condensed 3-(piperazinoalkyl)indol derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SOLVAY PHARM GMBH (DE) | 1998-11-11 | — | — | EP | disclosed |
| US-5324725-A | Antiinflammatory agent, antiallergen | KALI-CHEMIE PHARMA GMBH (DE) | 1994-06-28 | — | — | US | disclosed |
| EP-0529452-A2 | 1,7-Condensed 2-(piperazinoalkyl)indol derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | Kali-Chemie Pharma GmbH (DE) | 1993-03-03 | — | — | EP | disclosed |