Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.44 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.44 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554930 | 0.85 | GPBAR1 (0.62) | ALOX5PDE10AGPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL8555090 | 0.85 | GPBAR1 (0.61) | ALOX5PDE10AGPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL8557400 | 0.83 | GPBAR1 (0.45) | ALOX5PDE10AGPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL8552915 | 0.82 | GPBAR1 (0.44) | ALOX5PDE10AGPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL8557020 | 0.78 | GPBAR1 (0.46) | ALOX5PDE10AGPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL8890687 | 0.75 | GPBAR1 (0.68) | ALOX5PDE10AGPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL8559076 | 0.74 | KMT2A (0.40) | ALOX5GPBAR1ALOX5AP | |
| SCHEMBL8554714 | 0.74 | PARP10 (0.57) | — | |
| SCHEMBL8555940 | 0.73 | ADORA3 (0.41) | ALOX5PDE10AGPBAR1 | |
| SCHEMBL8890262 | 0.73 | GPBAR1 (0.62) | ALOX5PDE10AGPBAR1CYSLTR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5714488-A | FOR TREATMENT OF ALLERGIC AND INFLAMMATORY DISEASE STATES | ABBOTT LABORATORIES (US) | 1998-02-03 | — | — | US | claimed |
| US-5714488-A | FOR TREATMENT OF ALLERGIC AND INFLAMMATORY DISEASE STATES | ABBOTT LABORATORIES (US) | 1998-02-03 | — | — | US | disclosed |