Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559814 | 0.89 | PARP10 (0.45) | ADORA3GPBAR1PDE10APARP10HIF1A | |
| SCHEMBL8557149 | 0.85 | KMT2A (0.38) | ADORA3GPBAR1HIF1AKDM4EMAPT | |
| SCHEMBL8556878 | 0.84 | PPARD (0.50) | ADORA3ALOX5KDM4EMAPTRAB9A | |
| SCHEMBL8554714 | 0.82 | PARP10 (0.57) | PARP10MAPK14SMOKDM4EMAPT | |
| SCHEMBL8559076 | 0.82 | KMT2A (0.40) | GPBAR1PARP10ALOX5MAPK14SMO | |
| SCHEMBL8554930 | 0.81 | GPBAR1 (0.62) | GPBAR1PDE10AALOX5 | |
| SCHEMBL8555090 | 0.80 | GPBAR1 (0.61) | GPBAR1PDE10AALOX5 | |
| SCHEMBL8557020 | 0.80 | GPBAR1 (0.46) | GPBAR1PDE10AHIF1AALOX5MAPT | |
| SCHEMBL8626716 | 0.77 | NPC1 (0.54) | ALOX5KDM4EMAPTRAB9AALDH1A1 | |
| SCHEMBL8622650 | 0.76 | NPC1 (0.53) | ALOX5KDM4EMAPTRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5714488-A | FOR TREATMENT OF ALLERGIC AND INFLAMMATORY DISEASE STATES | ABBOTT LABORATORIES (US) | 1998-02-03 | — | — | US | disclosed |