Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.45 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.42 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552915 | 0.99 | GPBAR1 (0.44) | GPBAR1CYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL8554930 | 0.86 | GPBAR1 (0.62) | GPBAR1CYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL8555090 | 0.85 | GPBAR1 (0.61) | GPBAR1CYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL8557907 | 0.83 | ALOX5 (0.49) | GPBAR1CYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL8557020 | 0.79 | GPBAR1 (0.46) | GPBAR1CYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL8890687 | 0.75 | GPBAR1 (0.68) | GPBAR1CYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL8554714 | 0.75 | PARP10 (0.57) | MAOB | |
| SCHEMBL8555940 | 0.74 | ADORA3 (0.41) | GPBAR1PDE10AALOX5MRGPRX4MAOB | |
| SCHEMBL9054057 | 0.74 | NPC1 (0.55) | GPBAR1CYSLTR1CYSLTR2ALOX5ALOX5AP | |
| SCHEMBL8890262 | 0.74 | GPBAR1 (0.62) | GPBAR1CYSLTR1CYSLTR2PDE10AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5714488-A | FOR TREATMENT OF ALLERGIC AND INFLAMMATORY DISEASE STATES | ABBOTT LABORATORIES (US) | 1998-02-03 | — | — | US | claimed |
| US-5714488-A | FOR TREATMENT OF ALLERGIC AND INFLAMMATORY DISEASE STATES | ABBOTT LABORATORIES (US) | 1998-02-03 | — | — | US | disclosed |