Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HPD | P32754 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558148 | 1.00 | SMN1; SMN2 (0.39) | SMN1; SMN2PPARAPTGDR2MEN1KMT2A | |
| SCHEMBL8558240 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2PPARAPTGDR2MEN1KMT2A | |
| SCHEMBL4688521 | 0.77 | KDM4E (0.49) | MEN1KMT2AHPGDKDM4EPOLB | |
| SCHEMBL4688573 | 0.77 | PTGDR2 (0.42) | SMN1; SMN2PTGDR2MEN1KMT2APOLB | |
| SCHEMBL6998270 | 0.74 | MEN1 (0.43) | MEN1KMT2ANPC1HPGDRAB9A | |
| SCHEMBL8113280 | 0.69 | MEN1 (0.37) | MEN1KMT2AHPGDKDM4EHPD | |
| SCHEMBL7508888 | 0.69 | ALDH1A1 (0.51) | SMN1; SMN2MEN1KMT2ANPC1HPGD | |
| SCHEMBL12992926 | 0.69 | ALDH1A1 (0.42) | MEN1KMT2AHPGDKDM4EPOLB | |
| SCHEMBL7713466 | 0.69 | MEN1 (0.40) | PPARAMEN1KMT2AHPGDKDM4E | |
| SCHEMBL7704925 | 0.69 | MEN1 (0.40) | PPARAMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885210-A1 | Tricylic compounds having binding affinity for melatonin receptors, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032871-A1 | TRICYCLIC COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-09-12 | — | — | WO | disclosed |