Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 6/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558154 | 0.81 | SMN1; SMN2 (0.39) | SMN1; SMN2PPARAPTGDR2PPARGKDM4E | |
| SCHEMBL8558148 | 0.81 | SMN1; SMN2 (0.39) | SMN1; SMN2PPARAPTGDR2PPARGKDM4E | |
| SCHEMBL4684709 | 0.74 | PTGDR2 (0.40) | SMN1; SMN2PTGDR2KDM4EALDH1A1GLA | |
| SCHEMBL18936571 | 0.70 | SMN1; SMN2 (0.44) | SMN1; SMN2PPARAPTGDR2PPARGPPARD | |
| SCHEMBL7962725 | 0.69 | SMN1; SMN2 (0.58) | SMN1; SMN2PPARAPPARGMEN1KMT2A | |
| SCHEMBL7974243 | 0.69 | SMN1; SMN2 (0.48) | SMN1; SMN2PPARAPTGDR2PPARGKDM4E | |
| SCHEMBL7972678 | 0.68 | ALDH1A1 (0.45) | SMN1; SMN2PPARAPPARGKDM4EALDH1A1 | |
| SCHEMBL10788257 | 0.68 | SMN1; SMN2 (0.49) | SMN1; SMN2PPARAPTGDR2PPARGKDM4E | |
| SCHEMBL8326074 | 0.66 | GAA (0.50) | SMN1; SMN2PPARAKDM4EALDH1A1GAA | |
| SCHEMBL7976511 | 0.65 | SMN1; SMN2 (0.49) | SMN1; SMN2PPARAPTGDR2PPARGMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885210-A1 | Tricylic compounds having binding affinity for melatonin receptors, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032871-A1 | TRICYCLIC COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-09-12 | — | — | WO | disclosed |