Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | QDPR | P09417 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL457257 | 0.87 | HTR2C (0.32) | HTR2C | |
| SCHEMBL9330891 | 0.83 | NPC1 (0.36) | HTR2C | |
| SCHEMBL28119904 | 0.83 | NPC1 (0.33) | HTR2C | |
| SCHEMBL1777247 | 0.81 | NPC1 (0.38) | KMT2A | |
| SCHEMBL2097686 | 0.80 | QDPR (0.49) | HTR2CSLC18A3SIGMAR1HTR6QDPR | |
| SCHEMBL5106428 | 0.79 | HTR3A (0.41) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL27657802 | 0.79 | SLC6A2 (0.39) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL28108546 | 0.76 | SLC6A2 (0.39) | HTR2CSLC6A2SLC6A4SLC6A3SLC18A3 | |
| SCHEMBL27657806 | 0.73 | HTR2C (0.43) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL999284 | 0.72 | SLC18A3 (0.50) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1972911-A | 2-(1h-indolylsulfanyl)-aryl amine derivatives for use in the treatment of affective disorders, pain, adhd and stress urinary incontinence | LUNDBECK & CO AS H (DK) | 2007-05-30 | — | — | CN | disclosed |
| EP-0832076-A1 | NOVEL ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |