Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.66 |
| ▸ | LMNA | P02545 | 7/20 | 0.66 |
| ▸ | NPC1 | O15118 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | MMP2 | P08253 | 1/20 | 0.59 |
| ▸ | MMP9 | P14780 | 1/20 | 0.59 |
| ▸ | MMP8 | P22894 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | CCR6 | P51684 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3455930 | 0.82 | MAPT (0.52) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27482298 | 0.81 | MAPT (0.55) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30831170 | 0.80 | BCHE (0.59) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1879820 | 0.80 | BCHE (0.59) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3455929 | 0.78 | HTT (0.48) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14112761 | 0.77 | ALDH1A1 (0.60) | MAPTNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL31325602 | 0.77 | NPC1 (0.61) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17821366 | 0.77 | MYC (0.54) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3792726 | 0.76 | BCHE (0.68) | MAPTNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL5010434 | 0.75 | MMP2 (1.00) | MAPTLMNANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |