Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 7/20 | 0.53 |
| ▸ | AVPR2 | P30518 | 6/20 | 0.49 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558207 | 0.86 | AVPR2 (0.60) | HSD17B3AVPR2AVPR1A | |
| SCHEMBL8559036 | 0.84 | HPGD (0.50) | HSD17B3AVPR2AVPR1AHDAC1HDAC6 | |
| SCHEMBL8561962 | 0.80 | AVPR2 (0.58) | AVPR2AVPR1A | |
| SCHEMBL8562554 | 0.80 | AVPR2 (0.73) | AVPR2AVPR1A | |
| SCHEMBL8559571 | 0.80 | AVPR2 (0.62) | AVPR2AVPR1A | |
| SCHEMBL8556841 | 0.80 | AVPR2 (0.65) | AVPR2AVPR1A | |
| SCHEMBL8561780 | 0.78 | AVPR2 (0.54) | AVPR2AVPR1A | |
| SCHEMBL8565959 | 0.78 | AVPR2 (0.50) | AVPR2AVPR1A | |
| SCHEMBL8561645 | 0.78 | AVPR2 (0.58) | AVPR2AVPR1A | |
| SCHEMBL8563337 | 0.77 | AVPR2 (0.51) | HSD17B3AVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| WO-1997047624-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| WO-1997047625-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |