Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562358 | 0.81 | NPC1 (0.56) | SMN1; SMN2NPC1LMNARAB9AKDM4E | |
| SCHEMBL8557413 | 0.80 | NPC1 (0.55) | SMN1; SMN2NPC1LMNARAB9AKDM4E | |
| SCHEMBL8555910 | 0.79 | TRPV4 (0.47) | TRPV4SMN1; SMN2NPC1LMNARAB9A | |
| SCHEMBL8559376 | 0.77 | RAB9A (0.54) | SMN1; SMN2NPC1LMNARAB9AKDM4E | |
| SCHEMBL8556757 | 0.73 | MEN1 (0.66) | SMN1; SMN2LMNAKDM4EHSD17B10HPGD | |
| SCHEMBL8557533 | 0.73 | NPC1 (0.46) | SMN1; SMN2NPC1LMNARAB9AKDM4E | |
| SCHEMBL8557539 | 0.72 | TRPV4 (0.46) | TRPV4SMN1; SMN2NPC1LMNARAB9A | |
| SCHEMBL8561965 | 0.71 | NPC1 (0.52) | TRPV4SMN1; SMN2NPC1LMNARAB9A | |
| SCHEMBL8561960 | 0.71 | NPC1 (0.52) | SMN1; SMN2NPC1LMNARAB9AEGFR | |
| SCHEMBL23111889 | 0.69 | KDM4E (0.63) | SMN1; SMN2NPC1LMNARAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518731-B1 | 2-(Indol-2-yl-carbonylamino)-thiazole derivatives, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1998-08-26 | — | — | EP | disclosed |
| US-5380736-A | Cholecystokinin and gastric antagonist | ELF SANOFI (FR) | 1995-01-10 | — | — | US | disclosed |
| US-5314889-A | Hormone antagonists | ELF SANOFI (FR) | 1994-05-24 | — | — | US | disclosed |
| EP-0518731-A1 | Heterocyclic derivatives of substituted 2-acylamino 5-thiazole, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-12-16 | — | — | EP | disclosed |