Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 6/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557539 | 0.89 | TRPV4 (0.46) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL8561960 | 0.78 | NPC1 (0.52) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL8555910 | 0.78 | TRPV4 (0.47) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8556721 | 0.77 | TRPV4 (0.44) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8562358 | 0.77 | NPC1 (0.56) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL8557413 | 0.76 | NPC1 (0.55) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL8559376 | 0.76 | RAB9A (0.54) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL8556757 | 0.76 | MEN1 (0.66) | LMNASMN1; SMN2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL7208136 | 0.71 | NPC1 (1.00) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL29475123 | 0.71 | NPC1 (1.00) | NPC1RAB9ALMNASMN1; SMN2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518731-B1 | 2-(Indol-2-yl-carbonylamino)-thiazole derivatives, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1998-08-26 | — | — | EP | disclosed |
| US-5380736-A | Cholecystokinin and gastric antagonist | ELF SANOFI (FR) | 1995-01-10 | — | — | US | disclosed |
| US-5314889-A | Hormone antagonists | ELF SANOFI (FR) | 1994-05-24 | — | — | US | disclosed |
| EP-0518731-A1 | Heterocyclic derivatives of substituted 2-acylamino 5-thiazole, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-12-16 | — | — | EP | disclosed |