Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 5/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11389501 | 0.75 | ADORA1 (0.61) | ADORA1ADORA2AADORA2B | |
| SCHEMBL8563310 | 0.75 | ADORA2A (0.53) | ADORA1ADORA2AADORA2B | |
| SCHEMBL7951810 | 0.74 | ADORA1 (0.53) | ADORA1ADORA2AADORA2BSIRT1SIRT3 | |
| SCHEMBL8559082 | 0.71 | ADORA1 (0.62) | ADORA1ADORA2AADORA2B | |
| SCHEMBL7414170 | 0.71 | ADORA1 (0.52) | ADORA1ADORA2AADORA2BSIRT1SIRT3 | |
| SCHEMBL4623457 | 0.71 | ADORA2A (0.59) | ADORA1ADORA2AADORA2BSIRT1SIRT3 | |
| SCHEMBL9430500 | 0.70 | ADORA2A (0.60) | ADORA1ADORA2AADORA2BSIRT1SIRT3 | |
| SCHEMBL7420292 | 0.69 | ADORA1 (0.44) | ADORA1ADORA2AADORA2BSIRT1SIRT3 | |
| SCHEMBL8560002 | 0.68 | ADORA1 (0.58) | ADORA1ADORA2AADORA2B | |
| SCHEMBL27713795 | 0.68 | SIRT1 (0.68) | ADORA1ADORA2AADORA2BSIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880524-A1 | NEW TRIAZOLOPURINES, METHOD OF PREPARING THEM AND THEIR USE AS DRUGS | Boehringer Ingelheim Pharma KG (DE) | 1998-12-02 | — | — | EP | disclosed |
| WO-1998003511-A1 | NEW TRIAZOLOPURINES, METHOD OF PREPARING THEM AND THEIR USE AS DRUGS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1998-01-29 | — | — | WO | disclosed |