Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL251067 | 0.80 | PSMB8 (0.67) | PSMB8MAP2K1KCNMA1HTTTRPA1 | |
| SCHEMBL6427935 | 0.79 | PARP1 (0.53) | PSMB8MAP2K1KCNMA1HTTPARP1 | |
| SCHEMBL20305276 | 0.76 | PSMB8 (0.49) | PSMB8MAP2K1KCNMA1HTTPARP1 | |
| SCHEMBL15558409 | 0.75 | PSMB8 (0.41) | PSMB8MAP2K1KCNMA1PARP1CLK1 | |
| SCHEMBL20305418 | 0.73 | PIN1 (0.49) | PSMB8PARP1CNR2 | |
| SCHEMBL505010 | 0.72 | DHODH (0.58) | PARP1 | |
| SCHEMBL11739880 | 0.72 | PSMB8 (0.56) | PSMB8HTTPARP1 | |
| SCHEMBL110724 | 0.72 | MGAM (0.53) | — | |
| SCHEMBL8682741 | 0.72 | GAA (0.42) | PARP1 | |
| SCHEMBL9305381 | 0.72 | NOS1 (0.37) | PSMB8PARP1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0883622-A1 | PROTON PUMP INHIBITOR | APOTEX INC. (CA) | 1998-12-16 | — | — | EP | disclosed |
| EP-0883606-A1 | PROCESS FOR SCAVENGING THIOLS | APOTEX INC. (CA) | 1998-12-16 | — | — | EP | disclosed |
| WO-1997031923-A1 | PROTON PUMP INHIBITOR | APOTEX INC. (CA) | 1997-09-04 | — | — | WO | disclosed |
| WO-1997031893-A1 | PROCESS FOR SCAVENGING THIOLS | APOTEX INC. (CA) | 1997-09-04 | — | — | WO | disclosed |