Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | BRS3 | P32247 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562445 | 0.82 | ALDH1A1 (0.61) | ALDH1A1MCOLN3LMNASMN1; SMN2KDM4E | |
| SCHEMBL11228520 | 0.78 | ALDH1A1 (0.64) | ALDH1A1MCOLN3LMNASMN1; SMN2KDM4E | |
| SCHEMBL12481671 | 0.76 | ALDH1A1 (0.66) | ALDH1A1MCOLN3LMNASMN1; SMN2KDM4E | |
| SCHEMBL9259585 | 0.76 | BRS3 (0.45) | ALDH1A1LMNASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL4352952 | 0.73 | ALDH1A1 (0.48) | ALDH1A1MCOLN3LMNASMN1; SMN2KDM4E | |
| SCHEMBL15333501 | 0.73 | ALDH1A1 (0.61) | ALDH1A1MCOLN3LMNASMN1; SMN2KDM4E | |
| SCHEMBL15225912 | 0.73 | SMN1; SMN2 (0.59) | ALDH1A1MCOLN3LMNASMN1; SMN2KDM4E | |
| SCHEMBL6618815 | 0.73 | CA12 (0.47) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL8560216 | 0.72 | CA12 (0.41) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL29498544 | 0.71 | ALDH1A1 (0.52) | ALDH1A1MCOLN3LMNAMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| US-5459138-A | Dysfunctions of glutamatergic neurotransmission associated with learning and memory | ADIR ET COMPAGNIE (FR) | 1995-10-17 | — | — | US | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |