Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | BRS3 | P32247 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558650 | 0.82 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1MCOLN3LMNAHTT | |
| SCHEMBL28820135 | 0.78 | ALDH1A1 (0.97) | ALDH1A1L3MBTL1MCOLN3LMNAHTT | |
| SCHEMBL2875807 | 0.73 | ALDH1A1 (0.61) | ALDH1A1L3MBTL1MCOLN3LMNAHTT | |
| SCHEMBL15225912 | 0.73 | SMN1; SMN2 (0.59) | ALDH1A1MCOLN3LMNAHTTHPGD | |
| SCHEMBL8212413 | 0.73 | LMNA (0.49) | ALDH1A1LMNAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL7908992 | 0.72 | GSTO1 (0.45) | ALDH1A1LMNAKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL10455310 | 0.72 | ALDH1A1 (0.67) | ALDH1A1L3MBTL1MCOLN3LMNAHTT | |
| SCHEMBL10453953 | 0.71 | ALDH1A1 (0.77) | ALDH1A1L3MBTL1MCOLN3LMNAHTT | |
| SCHEMBL4000366 | 0.71 | ALDH1A1 (0.70) | ALDH1A1L3MBTL1MCOLN3LMNAHTT | |
| SCHEMBL5504038 | 0.71 | ALDH1A1 (0.61) | ALDH1A1L3MBTL1MCOLN3LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| US-5459138-A | Dysfunctions of glutamatergic neurotransmission associated with learning and memory | ADIR ET COMPAGNIE (FR) | 1995-10-17 | — | — | US | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |