Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAALAD2 | Q9Y3Q0 | 6/20 | 0.51 |
| ▸ | GGH | Q92820 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 5/20 | 0.46 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.46 |
| ▸ | CPA3 | P15088 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4560594 | 0.81 | MME (0.42) | NAALAD2FOLH1FFAR1ALDH1A1 | |
| SCHEMBL4560596 | 0.81 | MME (0.42) | NAALAD2FOLH1FFAR1ALDH1A1 | |
| SCHEMBL60371 | 0.74 | GAA (0.62) | NAALAD2GGHGAAMMP9MMP8 | |
| SCHEMBL60370 | 0.74 | GAA (0.62) | NAALAD2GGHGAAMMP9MMP8 | |
| SCHEMBL2368115 | 0.73 | GGH (0.58) | NAALAD2GGHGAAMMP9MMP8 | |
| SCHEMBL1818651 | 0.71 | NAALAD2 (0.60) | NAALAD2GGHGAAMMP9MMP8 | |
| SCHEMBL698067 | 0.71 | CA2 (0.67) | NAALAD2GGHGAAADAMTS4FOLH1 | |
| SCHEMBL715646 | 0.71 | CA2 (0.67) | NAALAD2GGHGAAADAMTS4FOLH1 | |
| SCHEMBL869873 | 0.71 | NAALAD2 (0.60) | NAALAD2GGHGAAMMP9MMP8 | |
| SCHEMBL97498 | 0.71 | CA2 (0.67) | NAALAD2GGHGAAADAMTS4FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843997-A | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1998-12-01 | — | — | US | disclosed |
| US-5576323-A | CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| EP-0658539-A1 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1995-06-21 | — | — | EP | disclosed |