Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10343209 | 0.94 | TLR8 (0.47) | TLR8MAPTGAAALDH1A1KDM4E | |
| SCHEMBL8179510 | 0.81 | CA12 (0.55) | TLR8MAPTGAAALDH1A1KDM4E | |
| SCHEMBL8188907 | 0.79 | CA12 (0.41) | TLR8ALDH1A1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL8188956 | 0.79 | TLR8 (0.53) | TLR8MAPTALDH1A1KDM4ENPC1 | |
| SCHEMBL10343253 | 0.78 | TLR8 (0.62) | TLR8 | |
| SCHEMBL10044374 | 0.72 | TLR8 (0.53) | TLR8 | |
| SCHEMBL21841734 | 0.71 | TLR8 (0.54) | TLR8 | |
| SCHEMBL28129049 | 0.71 | PRKAG1 (0.45) | TLR8MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL21841694 | 0.70 | TLR8 (0.53) | TLR8 | |
| SCHEMBL8179545 | 0.70 | TLR8 (0.60) | TLR8ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825186-A1 | 2-Aminobenzazepine derivatives and their use for the treatment of immunosuppression | PFIZER INC. (US) | 1998-02-25 | — | — | EP | disclosed |