Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559014 | 0.93 | MAPT (0.48) | MAPTPOLBTP53PTGDR2PGR | |
| SCHEMBL8560966 | 0.90 | AR (0.48) | MAPTPOLBPTGDR2ARMEN1 | |
| SCHEMBL8556744 | 0.88 | GRM5 (0.44) | PGRARHTR1AHTR7 | |
| SCHEMBL8557997 | 0.86 | AR (0.51) | MAPTPOLBPTGDR2RAB9AGAA | |
| SCHEMBL8553642 | 0.83 | AR (0.46) | MAPTPOLBPGRMAPK1RAB9A | |
| SCHEMBL8557266 | 0.82 | AR (0.51) | MAPTPOLBTP53PGRMAPK1 | |
| SCHEMBL8560603 | 0.82 | GRM5 (0.44) | MAPTPOLBPTGS2ARMEN1 | |
| SCHEMBL9025890 | 0.80 | AR (0.45) | ARMEN1KMT2A | |
| SCHEMBL8553921 | 0.80 | MEN1 (0.48) | RAB9AMEN1KMT2A | |
| SCHEMBL8559953 | 0.79 | AR (0.45) | MAPTPOLBPTGS2ARMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |