SCHEMBL8558798

SCHEMBL8558798

O=[N+]([O-])c1ccc2c(c1)NCN2Cc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 1/20 0.50
CASP3 P42574 1/20 0.50
CASP4 P49662 1/20 0.50
CASP7 P55210 1/20 0.50
CASP9 P55211 1/20 0.50
CASP6 P55212 1/20 0.50
CASP8 Q14790 1/20 0.50
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
ALDH1A1 P00352 3/20 0.44
LMNA P02545 1/20 0.44
KAT2B Q92831 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
RAB9A P51151 2/20 0.43
SIRT2 Q8IXJ6 2/20 0.42
SIRT1 Q96EB6 2/20 0.42
CYP2C19 P33261 3/20 0.42
CYP3A4 P08684 2/20 0.42
CYP2C9 P11712 2/20 0.42
MAPT P10636 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7029422 0.91 CASP1 (0.48) CASP1CASP3CASP4CASP7CASP9
SCHEMBL23768998 0.75 CASP1 (0.52) CASP1CASP3CASP4CASP7CASP9
SCHEMBL10511948 0.75 CASP1 (0.49) CASP1CASP3CASP4CASP7CASP9
SCHEMBL7032529 0.75 KCNJ1 (0.51) MEN1KMT2AALDH1A1MAPTACHE
SCHEMBL7032882 0.75 ALDH1A1 (0.51) MEN1KMT2AALDH1A1CYP2C19MAPT
SCHEMBL9304274 0.75 EPHX2 (0.57) KMT2AALDH1A1LMNACYP2C19CYP2C9
SCHEMBL2769306 0.75 CASP1 (0.51) CASP1CASP3CASP4CASP7CASP9
SCHEMBL8177410 0.75 DRD2 (0.49) CASP1CASP3CASP4CASP7CASP9
SCHEMBL3502333 0.74 AR (0.46) CASP1CASP3CASP4CASP7CASP9
SCHEMBL3596541 0.74 MAPK1 (0.47) CASP1CASP3CASP4CASP7CASP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0843671-A1 HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM GLAXO GROUP LIMITED (GB) 1998-05-27 EP disclosed
WO-1997003069-A1 HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM GLAXO GROUP LIMITED (GB) 1997-01-30 WO disclosed