Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8900703 | 1.00 | KMT2A (0.38) | KMT2AGLSKDM4EALDH1A1GAA | |
| Bromide SCHEMBL7614674 | 0.81 | L3MBTL1 (0.46) | KDM4EALDH1A1GAAHSD17B10L3MBTL1 | |
| Bromide SCHEMBL7614677 | 0.81 | L3MBTL1 (0.46) | KDM4EALDH1A1GAAHSD17B10L3MBTL1 | |
| Bromide SCHEMBL7880298 | 0.77 | MEN1 (0.43) | KMT2ACA12CA1CA2CA9 | |
| Bromide SCHEMBL7880295 | 0.77 | MEN1 (0.43) | KMT2ACA12CA1CA2CA9 | |
| Bromide SCHEMBL7619352 | 0.76 | HTT (0.45) | KMT2AALDH1A1HSD17B10L3MBTL1HRH3 | |
| Bromide SCHEMBL7619356 | 0.76 | HTT (0.45) | KMT2AALDH1A1HSD17B10L3MBTL1HRH3 | |
| Bromide SCHEMBL8564796 | 0.75 | ALDH1A1 (0.36) | KMT2AKDM4EALDH1A1 | |
| Bromide SCHEMBL8564801 | 0.75 | ALDH1A1 (0.36) | KMT2AKDM4EALDH1A1 | |
| Bromide SCHEMBL9076744 | 0.74 | MEN1 (0.40) | KMT2AALDH1A1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5804577-A | ANTIBIOTICS | HOFFMANN-LA ROCHE INC. (US) | 1998-09-08 | — | — | US | disclosed |
| EP-0761673-A1 | Cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-12 | — | — | EP | disclosed |