Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 5/20 | 0.70 |
| ▸ | EGFR | P00533 | 7/20 | 0.54 |
| ▸ | RET | P07949 | 5/20 | 0.54 |
| ▸ | KDR | P35968 | 3/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558954 | 0.93 | ERBB2 (0.63) | ERBB2EGFRRETKDRLCK | |
| SCHEMBL8093504 | 0.83 | ERBB2 (0.70) | ERBB2EGFRKDR | |
| SCHEMBL8555757 | 0.83 | ERBB2 (1.00) | ERBB2EGFRRETKDRLCK | |
| SCHEMBL8807988 | 0.82 | EGFR (0.67) | EGFRRETKDRLCKLRRK2 | |
| Hydrochloric Acid SCHEMBL8894722 | 0.82 | ERBB2 (0.98) | ERBB2EGFRRETKDRLCK | |
| SCHEMBL8807285 | 0.80 | EGFR (0.67) | EGFRRETKDRLCKLRRK2 | |
| SCHEMBL8556343 | 0.80 | KDR (0.72) | ERBB2EGFRRETKDRLCK | |
| Hydrochloric Acid SCHEMBL8896157 | 0.79 | KDR (0.70) | ERBB2EGFRRETKDRLCK | |
| SCHEMBL5746250 | 0.76 | AURKB (0.71) | ERBB2EGFRKDR | |
| SCHEMBL8555750 | 0.76 | ERBB2 (0.87) | ERBB2EGFRRETKDRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843671-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1998-05-27 | — | — | EP | claimed |
| WO-1997003069-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1997-01-30 | — | — | WO | claimed |
| EP-0843671-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1998-05-27 | — | — | EP | disclosed |
| WO-1997003069-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1997-01-30 | — | — | WO | disclosed |