Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 4/20 | 0.70 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 9/20 | 0.46 |
| ▸ | MET | P08581 | 8/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558960 | 0.83 | ERBB2 (0.70) | ERBB2EGFRKDR | |
| SCHEMBL8096012 | 0.81 | ERBB2 (0.73) | ERBB2EGFRKDRMETGRM1 | |
| SCHEMBL8558954 | 0.76 | ERBB2 (0.63) | ERBB2EGFRKDR | |
| SCHEMBL8554234 | 0.75 | MAPT (0.56) | — | |
| SCHEMBL11965408 | 0.72 | EGFR (0.78) | ERBB2EGFRGRM1 | |
| SCHEMBL6765471 | 0.70 | EGFR (0.53) | ERBB2EGFR | |
| SCHEMBL8554228 | 0.68 | XDH (0.46) | — | |
| SCHEMBL8082013 | 0.68 | EGFR (0.74) | ERBB2EGFRKDRGRM1 | |
| SCHEMBL8558474 | 0.68 | ERBB2 (1.00) | ERBB2EGFRKDRMET | |
| SCHEMBL7209149 | 0.67 | ALDH1A1 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | claimed |
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | disclosed |
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |