Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9903935 | 0.82 | CYP2D6 (0.60) | CYP3A4MAPTLMNACYP2D6 | |
| SCHEMBL28319646 | 0.81 | POLB (0.62) | MEN1KMT2AMAPTPOLBLMNA | |
| SCHEMBL2644131 | 0.80 | NPC1 (0.55) | CYP1A2CYP3A4CYP2C19NPC1RAB9A | |
| SCHEMBL3447074 | 0.78 | MAPT (0.62) | MEN1KMT2ACYP3A4NPC1RAB9A | |
| SCHEMBL2615553 | 0.78 | NPC1 (0.57) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL27617094 | 0.77 | RAB9A (0.56) | MEN1KMT2ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL1409064 | 0.77 | MEN1 (0.56) | MEN1KMT2ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL5142118 | 0.76 | SMN1; SMN2 (0.50) | KMT2ANPC1RAB9AMAPTPOLB | |
| SCHEMBL11831593 | 0.76 | RAB9A (0.51) | MEN1KMT2ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4781293 | 0.76 | NPC1 (0.55) | MEN1KMT2ANPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998051311-A2 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-11-19 | — | — | WO | disclosed |
| EP-0790826-A4 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0790826-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-08-27 | — | — | EP | disclosed |
| CN-1098718-A | Heterogeneous ring compound | ZENECA LTD (GB) | 1995-02-15 | — | — | CN | disclosed |