Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.43 |
| ▸ | CTSA | P10619 | 4/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559917 | 0.81 | CTSA (0.42) | PTGS2CTSAPTGDR2 | |
| SCHEMBL5732590 | 0.78 | PTGS2 (0.44) | PTGS2CTSAPTGDR2PTGS1 | |
| SCHEMBL5732775 | 0.75 | PTGS2 (0.42) | PTGS2CTSAPTGDR2PTGS1 | |
| SCHEMBL7504581 | 0.74 | PTGS2 (0.56) | PTGS2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6002182 | 0.74 | PTGS2 (0.41) | PTGS2CTSAPTGS1 | |
| SCHEMBL6002011 | 0.72 | PTGS2 (0.40) | PTGS2CTSAPTGS1 | |
| SCHEMBL8558001 | 0.72 | CTSA (0.41) | PTGS2CTSAPTGS1 | |
| SCHEMBL7509341 | 0.70 | PTGS2 (0.48) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL9896010 | 0.70 | EPHX2 (0.51) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL7509340 | 0.69 | PTGS2 (0.49) | PTGS2PTGS1MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |