Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 10/20 | 0.61 |
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.61 |
| ▸ | TSHR | P16473 | 4/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.61 |
| ▸ | MTOR | P42345 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.61 |
| ▸ | DRD2 | P14416 | 2/20 | 0.61 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559210 | 1.00 | ADRB2 (0.61) | ADRB2MAPTTDP1KDM4EADRB1 | |
| Oxalic Acid SCHEMBL8564309 | 0.94 | ADRB2 (0.56) | ADRB2MAPTTDP1KDM4EADRB1 | |
| Oxalic Acid SCHEMBL8564305 | 0.94 | ADRB2 (0.56) | ADRB2MAPTTDP1KDM4EADRB1 | |
| SCHEMBL8563377 | 0.92 | ADRB2 (0.64) | ADRB2MAPTTDP1KDM4EADRB1 | |
| SCHEMBL8563374 | 0.92 | ADRB2 (0.64) | ADRB2MAPTTDP1KDM4EADRB1 | |
| Oxalic Acid SCHEMBL8563561 | 0.86 | ADRB2 (0.58) | ADRB2MAPTTDP1KDM4EADRB1 | |
| Oxalic Acid SCHEMBL8633452 | 0.86 | ADRB2 (0.58) | ADRB2MAPTTDP1KDM4EADRB1 | |
| SCHEMBL8564322 | 0.82 | ADRA1A (0.39) | ADRB2MAPTTDP1KDM4EADRB1 | |
| SCHEMBL8562119 | 0.82 | ADRB2 (0.61) | ADRB2MAPTTDP1KDM4EADRB1 | |
| SCHEMBL8562122 | 0.82 | ADRB2 (0.61) | ADRB2MAPTTDP1KDM4EADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5775329-A | DERIVATIVES OF NOREPINEPHRINE USED TO STIMULATE EXERCISE STRESS AND ITS EFFECTS ON THE HEART. | GENSIA, INC. (US) | 1998-07-07 | — | — | US | claimed |
| US-5775329-A | DERIVATIVES OF NOREPINEPHRINE USED TO STIMULATE EXERCISE STRESS AND ITS EFFECTS ON THE HEART. | GENSIA, INC. (US) | 1998-07-07 | — | — | US | disclosed |
| US-5756730-A | Process for preparing analgesic compounds | SANKYO COMPANY, LIMITED (JP) | 1998-05-26 | — | — | US | disclosed |
| US-5656758-A | AMIDATION OF AN AMINE-CONTAINING THIOMORPHOLINE OR PIPERAZINE COMPOUND | SANKYO COMPANY, LIMITED (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5512567-A | KAPPA-RECEPTOR AGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-04-30 | — | — | US | disclosed |
| US-5270327-A | Piperidine derivatives | SANKYO COMPANY, LIMITED (JP) | 1993-12-14 | — | — | US | disclosed |
| EP-0356247-B1 | ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES | Sankyo Company Limited (JP) | 1993-03-17 | — | — | EP | disclosed |
| US-5021413-A | Analgesic thiomorpholins their preparation, and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1991-06-04 | — | — | US | disclosed |
| EP-0356247-A1 | Analgesic carboxylic acid amide derivatives | Sankyo Company Limited (JP) | 1990-02-28 | — | — | EP | disclosed |