Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MMP2 | P08253 | 3/20 | 0.44 |
| ▸ | MMP9 | P14780 | 3/20 | 0.44 |
| ▸ | MMP8 | P22894 | 3/20 | 0.44 |
| ▸ | MMP13 | P45452 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19810722 | 0.78 | MAPT (0.57) | MAPTSMN1; SMN2RAB9ANPC1MAPK1 | |
| SCHEMBL29980210 | 0.78 | MAPT (0.57) | MAPTSMN1; SMN2RAB9ANPC1MAPK1 | |
| SCHEMBL2114821 | 0.78 | HPGD (0.58) | MAPTSMN1; SMN2RAB9ANPC1HTT | |
| SCHEMBL29980222 | 0.78 | HPGD (0.58) | MAPTSMN1; SMN2RAB9ANPC1HTT | |
| SCHEMBL22926811 | 0.77 | ALDH1A1 (0.42) | MAPTSMN1; SMN2ALDH1A1LMNAGAA | |
| SCHEMBL19420096 | 0.77 | MAPT (0.58) | MAPTSMN1; SMN2MAPK1HTTALDH1A1 | |
| SCHEMBL31280487 | 0.76 | SMN1; SMN2 (0.63) | MAPTSMN1; SMN2RAB9ANPC1HTT | |
| SCHEMBL8560807 | 0.76 | MAPT (0.58) | MAPTSMN1; SMN2RAB9AMAPK1HTT | |
| SCHEMBL3389504 | 0.76 | KDM1A (0.53) | MAPTSMN1; SMN2RAB9ANPC1MAPK1 | |
| SCHEMBL8737022 | 0.76 | SMN1; SMN2 (0.63) | MAPTSMN1; SMN2RAB9ANPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |