Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.58 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL268150 | 0.83 | MEN1 (0.68) | MAPTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL3328543 | 0.82 | MAPT (0.79) | MAPTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL4163474 | 0.82 | MAPT (0.79) | MAPTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL6942228 | 0.82 | MEN1 (0.59) | MAPTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL57616 | 0.81 | LMNA (0.56) | MAPTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL29929890 | 0.81 | LMNA (0.56) | MAPTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL8934655 | 0.80 | MAPT (0.76) | MAPTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL8934649 | 0.80 | MAPT (0.76) | MAPTMEN1KMT2ASMN1; SMN2LMNA | |
| Fluoride SCHEMBL29135589 | 0.80 | MAPT (0.76) | MAPTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL2030452 | 0.80 | PDE7A (0.74) | MAPTKMT2ASMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |