Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.48 |
| ▸ | RXRB | P28702 | 5/20 | 0.48 |
| ▸ | RXRG | P48443 | 3/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560006 | 0.92 | RXRA (0.48) | RXRARXRBRXRGPTGS1EPHX2 | |
| SCHEMBL8558066 | 0.91 | NR4A2 (0.40) | RXRARXRBRXRGPTGS1EPHX2 | |
| SCHEMBL8559262 | 0.91 | NR4A2 (0.40) | RXRARXRBRXRGPTGS1EPHX2 | |
| SCHEMBL8561125 | 0.88 | PTGS2 (0.47) | RXRARXRBRXRGPTGS1EPHX2 | |
| SCHEMBL8559470 | 0.88 | RXRA (0.41) | RXRARXRBRXRGPTGS1EPHX2 | |
| SCHEMBL8555226 | 0.88 | RXRA (0.46) | RXRARXRBRXRGPTGS1PTGS2 | |
| SCHEMBL8555143 | 0.88 | RXRA (0.49) | RXRARXRBRXRGNR4A2F10 | |
| SCHEMBL8557928 | 0.87 | RXRA (0.47) | RXRARXRBRXRGNR4A2MAOB | |
| SCHEMBL8556768 | 0.87 | NR4A2 (0.45) | RXRARXRBRXRGPTGS1EPHX2 | |
| SCHEMBL8558990 | 0.86 | NR4A2 (0.39) | RXRARXRBRXRGPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |