Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | HRH1 | P35367 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4420923 | 0.80 | OPRL1 (0.42) | OPRL1TRPA1 | |
| SCHEMBL7471730 | 0.80 | OPRL1 (0.42) | OPRL1TRPA1 | |
| SCHEMBL11061195 | 0.71 | POLB (0.52) | OPRM1SLC6A4HRH1DRD2HTR6 | |
| SCHEMBL5629416 | 0.70 | CACNA1S (0.57) | OPRM1SLC6A4HRH1DRD2HTR6 | |
| SCHEMBL8083326 | 0.69 | ALDH1A1 (0.50) | LMNAADRA2A | |
| SCHEMBL4703310 | 0.69 | CYP1A2 (0.39) | OPRM1SLC6A4HRH1HTR6HTR2A | |
| SCHEMBL8561164 | 0.68 | CCKBR (0.59) | — | |
| SCHEMBL8540648 | 0.68 | CCKBR (0.63) | — | |
| SCHEMBL4110297 | 0.66 | TRPA1 (0.42) | OPRL1TRPA1 | |
| SCHEMBL4118837 | 0.66 | TRPA1 (0.42) | OPRL1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716953-A | MODIFIERS OF GASTRIN AND CHOLECYSTOKININS | GLAXO WELLCOME S.P.A. (IT) | 1998-02-10 | — | — | US | disclosed |