Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 9/20 | 0.55 |
| ▸ | AVPR2 | P30518 | 8/20 | 0.55 |
| ▸ | OXTR | P30559 | 2/20 | 0.54 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8564490 | 0.86 | AVPR1A (0.53) | AVPR1AAVPR2OXTRAVPR1BKMT2A | |
| SCHEMBL8556989 | 0.86 | AVPR1A (0.72) | AVPR1AAVPR2OXTR | |
| SCHEMBL8820429 | 0.86 | AVPR1A (0.69) | AVPR1AAVPR2OXTRAVPR1B | |
| SCHEMBL8558930 | 0.85 | AVPR2 (0.60) | AVPR1AAVPR2OXTRKMT2ANPC1 | |
| SCHEMBL8557460 | 0.84 | AVPR1A (0.64) | AVPR1AAVPR2OXTR | |
| SCHEMBL8564664 | 0.84 | NAMPT (0.47) | AVPR1AAVPR2OXTRAVPR1BKMT2A | |
| SCHEMBL8563752 | 0.83 | ALDH1A1 (0.57) | AVPR1AAVPR2OXTRAVPR1B | |
| SCHEMBL8558289 | 0.83 | AVPR2 (0.60) | AVPR1AAVPR2OXTRRAB9A | |
| SCHEMBL8561545 | 0.83 | MEN1 (0.74) | AVPR1AAVPR2OXTRKMT2AMEN1 | |
| SCHEMBL8556628 | 0.83 | AVPR2 (0.53) | AVPR1AAVPR2OXTRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |