Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | AVPR2 | P30518 | 4/20 | 0.46 |
| ▸ | AVPR1A | P37288 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | LDHB | P07195 | 1/20 | 0.44 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.43 |
| ▸ | OXTR | P30559 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557382 | 0.87 | AVPR2 (0.50) | NAMPTKMT2ANPC1HPGDRAB9A | |
| SCHEMBL8559570 | 0.84 | AVPR1A (0.55) | KMT2ANPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL8563056 | 0.83 | ALDH1A1 (0.48) | NAMPTKMT2ANPC1HPGDRAB9A | |
| SCHEMBL8561675 | 0.83 | NAMPT (0.50) | NAMPTAVPR1A | |
| SCHEMBL8558667 | 0.82 | NAMPT (0.54) | NAMPTNPC1HPGDRAB9AAVPR2 | |
| SCHEMBL7332706 | 0.82 | AVPR2 (0.47) | NAMPTKMT2AAVPR2AVPR1AMEN1 | |
| SCHEMBL9234962 | 0.80 | AVPR1A (0.49) | KMT2AAVPR2AVPR1AMEN1 | |
| SCHEMBL8564490 | 0.80 | AVPR1A (0.53) | KMT2AAVPR2AVPR1AMEN1AVPR1B | |
| SCHEMBL8316010 | 0.80 | AVPR1A (0.40) | NAMPTKMT2AAVPR2AVPR1AMEN1 | |
| SCHEMBL8561545 | 0.77 | MEN1 (0.74) | NAMPTKMT2ANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |