SCHEMBL8559719

SCHEMBL8559719

Cc1ccc(N2CC(Cl)=C(Cl)C(=O)N2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 3/20 0.47
ALDH1A1 P00352 3/20 0.38
KDM4E B2RXH2 1/20 0.38
F2 P00734 1/20 0.37
ELANE P08246 1/20 0.37
CTSG P08311 1/20 0.37
CMA1 P23946 1/20 0.37
CTRC Q99895 1/20 0.37
MAPT P10636 2/20 0.36
MGLL Q99685 1/20 0.35
HPGD P15428 2/20 0.35
NPC1 O15118 2/20 0.35
LMNA P02545 2/20 0.35
RAB9A P51151 2/20 0.35
HSP90AA1 P07900 1/20 0.35
XBP1 P17861 1/20 0.35
MAPK1 P28482 1/20 0.35
HTT P42858 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8557804 0.83 POLB (0.37) ALOX5MGLLHPGDLMNANPSR1
SCHEMBL4183802 0.83 ALOX5 (0.44) ALOX5KDM4EMAPTHTTALOX15
SCHEMBL9637542 0.81 TRIM24 (0.39) ALOX5ALDH1A1KDM4ELMNAMAPK1
SCHEMBL8557134 0.79 ADAM17 (0.41) CTSGCMA1MAPTKMT2ACYP2C9
SCHEMBL8556304 0.75 ALOX5 (0.54) ALOX5ALDH1A1KDM4EMAPTMGLL
SCHEMBL9795754 0.69 ALOX5 (0.54) ALOX5F2ELANECTSGCMA1
SCHEMBL9779963 0.69 ALOX5 (0.50) ALOX5F2ELANECTSGCMA1
SCHEMBL11333725 0.67 ALOX5 (0.42) ALOX5KDM4EMAPTNPC1RAB9A
SCHEMBL3060656 0.66 CRBN (0.34)
SCHEMBL2382690 0.65 ALOX5 (1.00) ALOX5ALDH1A1F2ELANECTSG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0756598-B1 SUBSTITUTED 5,6-DIHYDRO-5-OXO-1,4-DITHIINO-(2,3-D)-PYRIDAZINE-2,3-DICARBONITRILES, COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIMICROBIALS DOW CHEMICAL CO (US) 1998-09-16 EP disclosed
EP-0756598-A1 SUBSTITUTED 5,6-DIHYDRO-5-OXO-1,4-DITHIINO-(2,3-D)-PYRIDAZINE-2,3-DICARBONITRILES, COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIMICROBIALS THE DOW CHEMICAL COMPANY (a Delaware corporation) (US) 1997-02-05 EP disclosed
US-5488051-A BACTERICIDES, FUNGICIDES, ALGICIDES AND ANTIPROTOZOA AGENTS THE DOW CHEMICAL COMPANY (US) 1996-01-30 US disclosed
WO-1995029181-A1 SUBSTITUTED 5,6-DIHYDRO-5-OXO-1,4-DITHIINO-(2,3-D)-PYRIDAZINE-2,3-DICARBONITRILES, COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIMICROBIALS THE DOW CHEMICAL COMPANY (US) 1995-11-02 WO disclosed