Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 3/20 | 0.39 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 5/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449849 | 0.77 | KDM4E (0.53) | HTR4CNR1CNR2HTR7KDM4E | |
| SCHEMBL8566824 | 0.69 | HTR4 (0.47) | HTR4HTR7KDM4EALDH1A1PMP22 | |
| SCHEMBL8521031 | 0.68 | HTR4 (0.46) | HTR4CNR1CNR2HTR7KDM4E | |
| SCHEMBL8574546 | 0.68 | HTR4 (0.46) | HTR4HTR7KDM4EALDH1A1PMP22 | |
| SCHEMBL8575502 | 0.67 | HTR4 (0.53) | HTR4HRH2HTR7 | |
| SCHEMBL8520377 | 0.67 | HTR4 (0.49) | HTR4HRH2HTR7KDM4EALDH1A1 | |
| SCHEMBL1077431 | 0.66 | HTR4 (0.50) | HTR4HRH2HTR7 | |
| SCHEMBL7400351 | 0.65 | HTR4 (0.43) | HTR4HRH2KDM4EALDH1A1PMP22 | |
| SCHEMBL9345077 | 0.65 | KDM4E (0.46) | HTR4KDM4EALDH1A1PMP22NPSR1 | |
| SCHEMBL9342316 | 0.65 | HTR4 (0.48) | HTR4HTR7KDM4EALDH1A1PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998409-A | GASTROINTESTINAL DISORDERS; CARDIOVASCULAR DISORDERS; NERVOUS SYSTEM DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1999-12-07 | — | — | US | disclosed |