Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566824 | 0.92 | HTR4 (0.47) | HTR4HTR7KDM4EALDH1A1PMP22 | |
| SCHEMBL8521031 | 0.82 | HTR4 (0.46) | HTR4HTR7KDM4EALDH1A1PMP22 | |
| SCHEMBL1077431 | 0.80 | HTR4 (0.50) | HTR4HTR7CHRM2ADRA2BHRH1 | |
| SCHEMBL8520377 | 0.77 | HTR4 (0.49) | HTR4HTR7KDM4EALDH1A1PMP22 | |
| SCHEMBL8575502 | 0.76 | HTR4 (0.53) | HTR4HTR7CHRM2ADRA2BHRH1 | |
| SCHEMBL8575712 | 0.76 | HTR4 (0.47) | HTR4HTR7CHRM2ADRA2BCHRM3 | |
| SCHEMBL7449849 | 0.71 | KDM4E (0.53) | HTR4HTR7KDM4EALDH1A1PMP22 | |
| SCHEMBL8574553 | 0.69 | HTR2A (0.39) | HTR4 | |
| SCHEMBL8560071 | 0.68 | HTR4 (0.41) | HTR4HTR7KDM4EALDH1A1PMP22 | |
| SCHEMBL7360838 | 0.68 | HTR4 (0.49) | HTR4KDM4EALDH1A1PMP22NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998409-A | GASTROINTESTINAL DISORDERS; CARDIOVASCULAR DISORDERS; NERVOUS SYSTEM DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1999-12-07 | — | — | US | disclosed |