Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.49 |
| ▸ | BRAF | P15056 | 6/20 | 0.49 |
| ▸ | KIT | P10721 | 4/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | ARNT | P27540 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566456 | 0.82 | KDR (0.58) | KDRBRAFKITFLT3GRM4 | |
| SCHEMBL8560980 | 0.75 | KDR (0.56) | KDRBRAFKITFLT3GRM4 | |
| SCHEMBL8562560 | 0.75 | BRAF (0.64) | KDRBRAFKITFLT3GRM4 | |
| SCHEMBL7178922 | 0.71 | GRM4 (0.86) | KDRBRAFKITFLT3GRM4 | |
| SCHEMBL8568008 | 0.71 | PDE7A (0.44) | LMNA | |
| SCHEMBL8562462 | 0.69 | KDR (0.54) | KDRBRAFKITFLT3GRM4 | |
| SCHEMBL8563685 | 0.69 | KDR (0.54) | KDRBRAFKITFLT3GRM4 | |
| SCHEMBL4555026 | 0.69 | LMNA (0.75) | KDRBRAFGRM4LMNATRPV1 | |
| SCHEMBL8565704 | 0.69 | KDR (0.58) | KDRBRAFKITFLT3GRM4 | |
| SCHEMBL8561654 | 0.69 | KDR (0.58) | KDRBRAFKITFLT3GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |