Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | PPARA | Q07869 | 6/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.43 |
| ▸ | CTRC | Q99895 | 2/20 | 0.43 |
| ▸ | GLB1 | P16278 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8564013 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2NPSR1PPARAALOX5LOXL2 | |
| SCHEMBL8561692 | 0.78 | HPGD (0.58) | SMN1; SMN2NPSR1USP2LMNAMAPT | |
| SCHEMBL8523609 | 0.77 | SMN1; SMN2 (0.74) | SMN1; SMN2NPSR1PPARAALOX5LOXL2 | |
| SCHEMBL1748171 | 0.74 | SMN1; SMN2 (1.00) | SMN1; SMN2NPSR1PPARAALOX5LOXL2 | |
| SCHEMBL30602946 | 0.74 | SMN1; SMN2 (1.00) | SMN1; SMN2NPSR1PPARAALOX5LOXL2 | |
| SCHEMBL12584997 | 0.73 | SMN1; SMN2 (0.58) | SMN1; SMN2NPSR1PPARAALOX5LOXL2 | |
| SCHEMBL11601529 | 0.72 | SMN1; SMN2 (0.57) | SMN1; SMN2NPSR1PPARAALOX5LOXL2 | |
| SCHEMBL9622398 | 0.72 | SMN1; SMN2 (0.71) | SMN1; SMN2NPSR1PPARAALOX5TMEM97 | |
| SCHEMBL31038096 | 0.72 | FBP1 (0.74) | SMN1; SMN2NPSR1MEN1LMNAMAPT | |
| SCHEMBL30423143 | 0.72 | SMN1; SMN2 (0.71) | SMN1; SMN2NPSR1PPARAALOX5TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |