Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.46 |
| ▸ | RXRB | P28702 | 7/20 | 0.46 |
| ▸ | RXRG | P48443 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557473 | 0.92 | NR4A2 (0.44) | RXRARXRBRXRGALDH1A1MAPT | |
| SCHEMBL8555226 | 0.91 | RXRA (0.46) | RXRARXRBRXRGALDH1A1MAPT | |
| SCHEMBL8556041 | 0.90 | RXRA (0.47) | RXRARXRBRXRGALDH1A1MAPT | |
| SCHEMBL8560576 | 0.89 | RXRA (0.46) | RXRARXRBRXRGALDH1A1MAPT | |
| SCHEMBL8559710 | 0.89 | PTGS2 (0.42) | RXRARXRBRXRGNR4A2PTGS1 | |
| SCHEMBL8560006 | 0.88 | RXRA (0.48) | RXRARXRBRXRGLMNANR4A2 | |
| SCHEMBL8556149 | 0.88 | RXRA (0.49) | RXRARXRBRXRGALDH1A1MAPT | |
| SCHEMBL8559346 | 0.86 | NR4A2 (0.48) | RXRARXRBRXRGALDH1A1MAPT | |
| SCHEMBL8561449 | 0.86 | RXRA (0.40) | RXRARXRBALDH1A1MAPTLMNA | |
| SCHEMBL8558703 | 0.86 | RXRA (0.49) | RXRARXRBRXRGALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |