Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 4/20 | 0.49 |
| ▸ | RXRB | P28702 | 4/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 5/20 | 0.36 |
| ▸ | CA1 | P00915 | 5/20 | 0.36 |
| ▸ | CA2 | P00918 | 5/20 | 0.36 |
| ▸ | CA9 | Q16790 | 5/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559383 | 0.96 | RXRA (0.47) | RXRARXRBNR4A2ALDH1A1LMNA | |
| SCHEMBL8561449 | 0.92 | RXRA (0.40) | RXRARXRBNR4A2ALDH1A1LMNA | |
| SCHEMBL8559346 | 0.90 | NR4A2 (0.48) | RXRARXRBNR4A2ALDH1A1LMNA | |
| SCHEMBL8556401 | 0.90 | CYP2C9 (0.40) | RXRARXRBNR4A2ALDH1A1LMNA | |
| SCHEMBL8557401 | 0.88 | NR4A2 (0.46) | RXRARXRBNR4A2ALDH1A1LMNA | |
| SCHEMBL8553816 | 0.88 | MAPT (0.40) | RXRARXRBNR4A2ALDH1A1LMNA | |
| SCHEMBL8560340 | 0.86 | RXRA (0.46) | RXRARXRBNR4A2ALDH1A1LMNA | |
| SCHEMBL8553420 | 0.86 | MAPT (0.40) | RXRARXRBNR4A2ALDH1A1LMNA | |
| SCHEMBL8560006 | 0.85 | RXRA (0.48) | RXRARXRBNR4A2LMNAPTGES2 | |
| SCHEMBL8556149 | 0.85 | RXRA (0.49) | RXRARXRBNR4A2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |