Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 3/20 | 0.42 |
| ▸ | RXRB | P28702 | 2/20 | 0.42 |
| ▸ | RARB | P10826 | 8/20 | 0.40 |
| ▸ | RARG | P13631 | 8/20 | 0.40 |
| ▸ | RARA | P10276 | 7/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | BLVRB | P30043 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561925 | 0.84 | CTSS (0.50) | CTSKCTSSRXRARXRBRARB | |
| SCHEMBL8561391 | 0.81 | CTSS (0.48) | CTSKCTSSRARGCYP3A4MEN1 | |
| SCHEMBL8748829 | 0.80 | RARB (0.55) | RXRARXRBRARBRARGRARA | |
| SCHEMBL8558167 | 0.80 | CTSS (0.40) | CTSKCTSSRXRARXRBRARB | |
| SCHEMBL8100687 | 0.79 | CYP3A4 (0.47) | CYP3A4KMT2AALDH1A1TSHR | |
| SCHEMBL8557343 | 0.79 | CTSS (0.48) | CTSKCTSSRXRARXRBCYP26A1 | |
| SCHEMBL8100983 | 0.78 | RARB (0.44) | CTSKCTSSRXRARXRBRARB | |
| SCHEMBL8106743 | 0.78 | MEN1 (0.42) | CTSKCTSSRXRARXRBRARB | |
| SCHEMBL8102431 | 0.77 | RARB (0.43) | CTSKCTSSRXRARXRBRARB | |
| SCHEMBL8757257 | 0.77 | RARB (0.40) | CTSKCTSSRXRARXRBRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5709867-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-01-20 | — | — | US | claimed |
| US-5709867-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-01-20 | — | — | US | disclosed |