Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 5/20 | 0.50 |
| ▸ | CTSK | P43235 | 4/20 | 0.50 |
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 5/20 | 0.39 |
| ▸ | RARG | P13631 | 5/20 | 0.39 |
| ▸ | RARA | P10276 | 4/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561391 | 0.87 | CTSS (0.48) | CTSSCTSKCYP3A4CTSBCTSL | |
| SCHEMBL8560537 | 0.84 | CTSK (0.44) | CTSSCTSKRXRARXRBCYP26A1 | |
| SCHEMBL8557343 | 0.83 | CTSS (0.48) | CTSSCTSKRXRARXRBCYP26A1 | |
| SCHEMBL8556496 | 0.79 | RXRA (0.47) | RXRARXRBCYP26A1CYP3A4CYP26B1 | |
| SCHEMBL8748829 | 0.78 | RARB (0.55) | RXRARXRBCYP26A1CYP3A4CYP26B1 | |
| SCHEMBL8100687 | 0.78 | CYP3A4 (0.47) | CYP3A4 | |
| SCHEMBL8100983 | 0.77 | RARB (0.44) | CTSSCTSKRXRARXRBCYP26A1 | |
| SCHEMBL8558167 | 0.76 | CTSS (0.40) | CTSSCTSKRXRARXRBCYP26A1 | |
| SCHEMBL8106743 | 0.76 | MEN1 (0.42) | CTSSCTSKRXRARXRBCYP26A1 | |
| SCHEMBL8102431 | 0.76 | RARB (0.43) | CTSSCTSKRXRARXRBCYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5709867-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-01-20 | — | — | US | disclosed |