Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | EDNRB | P24530 | 5/20 | 0.42 |
| ▸ | EDNRA | P25101 | 5/20 | 0.42 |
| ▸ | ACLY | P53396 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025484 | 0.96 | KDM4E (0.48) | KDM4EKMT2AALDH1A1EDNRBEDNRA | |
| SCHEMBL8556794 | 0.88 | KMT2A (0.52) | KDM4EKMT2AALDH1A1HSD17B10HPGD | |
| SCHEMBL8554887 | 0.87 | NR4A2 (0.54) | KDM4EKMT2AALDH1A1EDNRBEDNRA | |
| SCHEMBL9026644 | 0.81 | KMT2A (0.45) | KDM4EKMT2AALDH1A1HSD17B10HPGD | |
| SCHEMBL8556510 | 0.80 | KDM4E (0.51) | KDM4EKMT2AALDH1A1ACLYHSD17B10 | |
| SCHEMBL8561174 | 0.80 | TSHR (0.44) | KDM4EKMT2AALDH1A1EDNRBEDNRA | |
| SCHEMBL5694177 | 0.79 | EDNRB (0.51) | KDM4EKMT2AALDH1A1EDNRBEDNRA | |
| SCHEMBL8558225 | 0.78 | NR4A2 (0.48) | KDM4EKMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL8555394 | 0.76 | NR4A2 (0.47) | KDM4EKMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL8557632 | 0.76 | NR4A2 (0.57) | KDM4EKMT2AALDH1A1EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |