Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PLEC | Q15149 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556794 | 0.92 | KMT2A (0.52) | KMT2ACYP2C9MEN1TSHRTP53 | |
| SCHEMBL8560795 | 0.87 | EDNRB (0.43) | KMT2ACYP2C9MEN1TSHRMAPT | |
| SCHEMBL8556328 | 0.84 | KDM4E (0.51) | KMT2ACYP2C9MEN1TSHRTP53 | |
| SCHEMBL8560610 | 0.82 | ALDH1A1 (0.45) | KMT2ACYP2C9MEN1TSHRTP53 | |
| SCHEMBL8558805 | 0.82 | ALDH1A1 (0.53) | KMT2ACYP2C9MEN1TSHRTP53 | |
| SCHEMBL8560588 | 0.81 | KDM4E (0.51) | KMT2AMEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL8558727 | 0.79 | MAPT (0.45) | KMT2AMEN1TP53MAPTSMN1; SMN2 | |
| SCHEMBL8558225 | 0.79 | NR4A2 (0.48) | KMT2ACYP2C9MEN1TSHRALDH1A1 | |
| SCHEMBL9025484 | 0.78 | KDM4E (0.48) | KMT2AMEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL8557447 | 0.78 | RXRA (0.59) | TSHRKDM4EHPGDCYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |