Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.41 |
| ▸ | EDNRB | P24530 | 2/20 | 0.40 |
| ▸ | EDNRA | P25101 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558805 | 0.90 | ALDH1A1 (0.53) | TSHRPKMALDH1A1NR4A2NR4A1 | |
| SCHEMBL8558225 | 0.89 | NR4A2 (0.48) | TSHRPKMHPGDMAPK1NPSR1 | |
| SCHEMBL8557632 | 0.88 | NR4A2 (0.57) | TSHRHPGDMAPK1KDM4EALDH1A1 | |
| SCHEMBL8555394 | 0.87 | NR4A2 (0.47) | TSHRPKMHPGDMAPK1NPSR1 | |
| SCHEMBL8558261 | 0.83 | HSD11B1 (0.44) | TSHRHPGDNPSR1KDM4EALDH1A1 | |
| SCHEMBL8555072 | 0.83 | SLC40A1 (0.45) | TSHRHPGDNPSR1KDM4EALDH1A1 | |
| SCHEMBL8556328 | 0.81 | KDM4E (0.51) | TSHRHPGDMAPK1KDM4EALDH1A1 | |
| SCHEMBL8555950 | 0.81 | TSHR (0.44) | TSHRPKMHPGDMAPK1NPSR1 | |
| SCHEMBL8557447 | 0.81 | RXRA (0.59) | TSHRHPGDMAPK1KDM4ENR4A2 | |
| SCHEMBL8560795 | 0.81 | EDNRB (0.43) | TSHRHPGDNPSR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |