Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.64 |
| ▸ | HTR1A | P08908 | 3/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | HTR1D | P28221 | 8/20 | 0.61 |
| ▸ | HTR1B | P28222 | 5/20 | 0.61 |
| ▸ | DRD2 | P14416 | 2/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | MPO | P05164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557793 | 0.94 | KDM4E (0.59) | HTR7HTR1DHTR1BDRD2CHRM2 | |
| SCHEMBL8554831 | 0.92 | HTR7 (0.61) | HTR7HTR1ASLC6A4KCNH2HTR1D | |
| SCHEMBL8557097 | 0.91 | HTR1A (0.70) | HTR7HTR1ASLC6A4KCNH2DRD2 | |
| SCHEMBL8560920 | 0.90 | HTR7 (0.65) | HTR7 | |
| SCHEMBL27431034 | 0.88 | HTR1A (0.57) | HTR7HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL8557344 | 0.87 | HTR1A (0.76) | HTR7HTR1ASLC6A4KCNH2DRD2 | |
| SCHEMBL8556927 | 0.87 | HTR7 (0.68) | HTR7HTR1ASLC6A4KCNH2HTR1D | |
| SCHEMBL8558340 | 0.87 | HTR1A (0.60) | HTR7HTR1ASLC6A4DRD2HTR2A | |
| SCHEMBL8559489 | 0.87 | HTR1A (0.60) | HTR7HTR1ASLC6A4DRD2HTR2A | |
| SCHEMBL8557795 | 0.87 | KDM4E (0.52) | HTR7HTR1DHTR1BDRD2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |