Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.59 |
| ▸ | DRD3 | P35462 | 3/20 | 0.57 |
| ▸ | HTR7 | P34969 | 2/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | HRH2 | P25021 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2976824 | 0.85 | DRD2 (0.58) | DRD2DRD3HTR7DRD4HRH2 | |
| Hydrochloric Acid SCHEMBL2988937 | 0.85 | DRD2 (0.58) | DRD2DRD3HTR7DRD4HRH2 | |
| SCHEMBL6031843 | 0.81 | DRD2 (0.64) | DRD2DRD3HTR7DRD4HRH2 | |
| SCHEMBL8606553 | 0.81 | DRD2 (0.64) | DRD2DRD3HTR7DRD4HRH2 | |
| SCHEMBL8569200 | 0.81 | DRD2 (0.69) | DRD2DRD3HTR7ADRA1DADRA1A | |
| SCHEMBL7269404 | 0.80 | KDM4E (0.53) | DRD2DRD3HTR7DRD4HTR1A | |
| Hydrochloric Acid SCHEMBL8570034 | 0.80 | DRD2 (0.67) | DRD2DRD3HTR7ADRA1DADRA1A | |
| SCHEMBL5800584 | 0.80 | HTR1A (0.62) | DRD2HTR7ADRA1DADRA1AADRA1B | |
| SCHEMBL4404160 | 0.80 | DRD2 (0.75) | DRD2DRD3HTR7ADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL5801035 | 0.79 | HTR1A (0.61) | DRD2HTR7ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5334715-A | For treating psychological disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-08-02 | — | — | US | claimed |
| EP-0494604-B1 | 1-Piperazinyl-2-butenes and 2-butynes, intermediates thereof, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-10-07 | — | — | EP | disclosed |
| EP-0511610-B1 | Benzisothiazole- and benzisoxazole-3-carboxamides, a process for their preparation and their use as antipsychotic medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-09-11 | — | — | EP | disclosed |
| US-5440048-A | Treating psychoses | HOECHST-ROUSSEL PHARMACEUTICALS INC (US) | 1995-08-08 | — | — | US | disclosed |
| US-5334715-A | For treating psychological disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-08-02 | — | — | US | disclosed |
| US-5225412-A | Antipsychotic | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-06 | — | — | US | disclosed |
| US-5194436-A | For trating psychosis | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-03-16 | — | — | US | disclosed |
| EP-0511610-A1 | Benzisothiazole- and benzisoxazole-3-carboxamides, a process for their preparation and their use as antipsychotic medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-11-04 | — | — | EP | disclosed |
| US-5143923-A | Psychological disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-09-01 | — | — | US | disclosed |
| EP-0494604-A1 | 1-Piperazinyl-2-butenes and 2-butynes, intermediates thereof, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-07-15 | — | — | EP | disclosed |
| US-5130315-A | Treatment of psychosis | Wittekind, Raymond R. (US) | 1992-07-14 | — | — | US | disclosed |